Selected Scientific Literature and
References
Below are a number of scientific articles and references pertinent
to C’elle and stem cells in general. Check this
section frequently for updates and new information.
- Regenerative Medicine 2006: A
good overview of stem cells and some of the emerging therapies
that they being used for, compiled by the National Institutes
of Health. stemcells.nih.gov
- A.N. Patel, L. Geffner, R.F. Vina, J. Saslavsky, H.C. Urschel
Jr, R. Kormos, F. Benetti, Surgical treatment for congestive
heart failure with autologous adult stem cell transplantation:
A prospective randomized study. Journal of Thoracic
and Cardiovascular Surgery (2005) pp. 1631-1638.
In this study, adult stem cells were transplanted in a group
of patients undergoing cardiac bypass surgery and compared
to a similar group undergoing bypass surgery without stem cell
transplantation. The group who received adult stem cell
transplantation in addition to bypass surgery showed a significant
improvement in heart function compared to the group who did
not receive stem cell treatment. jtcs.ctsnetjournals.org
- M. Zurita and J. Vaquero, Functional recovery in chronic
paraplegia after bone marrow stromal cells transplantation. Neuroreport
15 (7) (2004), pp. 1105-1108.
This study examined the use of bone marrow stromal cells,
which are similar in function to C’elle menstrual stem
cells, in treating spinal cord damage in rats. The results
demonstrated a clear and progressive functional recovery of
the animals treated with the stem cells, providing a rationale
suggesting the utility of stem cell transplants in treating
chronic paraplegia. neuroreport.com
- B. Pelacho, Y. Nakamura, J. Zhang, J. Ross, Y. Heremans,
M. Nelson-Holte, B. Lemke, J. Hagenbrock, Y. Jiang, F.
Prosper, A. Luttun, C. Verfaillie, Multipotent adult progenitor
cell transplantation increases vascularity and imporves left
ventricular function after myocardial infarction. Journal
of Tissue Engineering and Regenerative Medicine (2007), pp.
51-59.
An animal study showing that the transplantation of multipotent
stem cells with similarities to C’elle significantly
improved cardiac function after heart attack. interscience.wiley.com
- N.H. Cho, Y.K. Park, Y.T. Kim, H. Yang, S.K. Kim. Lifetime
expression of stem cell markers in the uterine endometrium. Fertility
and Sterility 81 (2) (2005), pp. 403-407.
This paper shows evidence that stem cells are present continuously
in the endometrial lining of the uterus, and that some of the
cells, like C’elle, have the potential for differentiation
into mesenchymal stem cells. fertstert.org
- S.J. Greco, K. Liu, P. Rameshwar. Functional Similarities
among Genes Regulated by OCT4 in Human Mesenchymal and Embryonic
Stem Cells. Stem Cells (2007) e-publication ahead of
print.
A key gene that regulates pluripotency in embryonic stem cells
and gives them their properties was also found in mesenchymal
stem cells similar to C’elle and appears to have the
similar ability to regulate both embryonic and mesenchymal
stem cells. This is evidence for similar usefulness in
embryonic stem cells and mesenchymal stem cells, which are
adult in nature and generally from non-controversial sources.
stemcells.alphamedpress.org
- E.J. Gang, D. Bosnakovski, C.A. Figureido, J.W. Visser,
R.C. Perlingeiro. SSEA-4 identifies mesenchymal stem
cells from bone marrow. Blood. 109(4) (2007), pp. 1743-1751.
SSEA-4, a key marker in embryonic stem cells for pluripotency,
was also found in this paper to identify the adult mesenchymal
stem cell population in bone marrow, meaning that the adult
mesenchymal stem cells in bone marrow have the same potential
ability to become other cell types. Adult mesenchymal
stem cells found in bone marrow are similar to C’elle
menstrual stem cells, including the expression of SSEA-4.
bloodjournal.hematologylibrary.org
- C. Matthai, R. Horvat, M. Noe, F. Nagele, A. Radjabi, M.
von Trotsenburg, J. Huber, A. Kolbus. Oct-4 expression
in human endometrium. Molecular Human Reproduction
12(1)(2006), pp. 7-10.
The first study demonstrating Oct-4, a key marker for pluripotency
of stem cells, in human endometrium, the source of C’elle
menstrual stem cells. molehr.oxfordjournals.org
- R.W. Chan, K.E. Schwab, C.E. Gargett. Clonogenicity of
human endometrial and stromal cells. Biology of Reproduction
70 (6) (2004), pp.1738-1750.
This paper examines the presence of clonogenicity, a key stem-cell
property, in human endometrium and provides evidence of its
existence, demonstrating that stem cells such as the C’elle
menstrual stem cell are present in the endometrial lining of
the uterus. biolreprod.org
- C.E. Gargett, Identification and characterisation of human
endometrial stem/progenitor cells. The Australian and
New Zealand Journal of Obstetrics and Gynaecology 46(3) (2006),
pp.250-253.
Using clonal analysis, populations likely to be endometrial
stem/progenitor cells such as C’elle were found in human
endometrial tissue. blackwell-synergy.com
- J.J. Minguell, A. Erices, and P. Conget, Mesenchymal stem
cells. Experiemental Biology and Medicine 226 (2001),
pp.507-520.
This article reviews information on mesenchymal stem cells,
similar to C’elle, and disusses questions germane to
their use in cell therapies. ebonline.org